Which of these 3 hormones suppresses appetite and increases energy expenditure
Heather Arranie 
The post discusses three hormones that play a role in weight loss – ghrelin, leptin, and PYY. Ghrelin is known to stimulate appetite, while leptin and PYY are known to suppress appetite. The post asks which of these three hormones has the strongest effect on weight loss.
There is no clear answer to the question about which of these three hormones has the strongest effect on weight loss, since all three are known to have an effect on weight loss. Ghrelin stimulates appetite, while leptin and PYY are known to suppress appetite. However, some researchers feel that ghrelin may play a more significant role in weight loss than either leptin or PYY, since it is the only hormone of the three that directly stimulates appetite.
However, more research is needed to determine which of these hormones has the strongest effect on weight loss. In the meantime, anyone trying to lose weight should focus on eating healthy foods and exercising regularly, regardless of which of these hormones is most important for weight loss.
Ghrelin is produced by the stomach and signals to the hypothalamus when the body needs more food. It stimulates appetite through ghrelin receptors in the hypothalamus, which then signal to another part of the brain to increase food intake.
Leptin is produced by adipose tissue and signals to the brain when the body has had enough food. It decreases appetite by acting on leptin receptors in the hypothalamus.
PYY is released from the small intestine after eating and inhibits hunger signals from the hypothalamus.
Insulin also plays an important role in weight regulation by signaling cells to store or release sugar from the blood into our cells for energy production. The amount of sugar in the blood affects our hunger signals.
When there is too much sugar in the blood, insulin tells cells to store it so it cannot be used for energy production. When there is not enough sugar in the blood, insulin tells cells to release glucose into the bloodstream for energy production. This cycle ‘primes’ the body for hunger or satiety, which can be affected by meal timing and composition.
Leptin’s effects are distinct from the other two hormones’ effects; leptin signaling acts more directly on the hypothalamus to suppress appetite. Ghrelin stimulates appetite by acting on ghrelin receptors in the hypothalamus. PYY also inhibits appetite like leptin but works through a different mechanism to suppress appetite.
Hypothalamic neuropeptide Y (NPY) is involved in regulating feeding behavior and metabolism. NPY induces hunger by stimulating hypothalamic neurons that ultimately target the brainstem to increase food intake. NPY expression increases with fasting or caloric restriction, contributing to increased energy demand during times of low caloric intake.
The conclusion that ghrelin is most important for weight loss is a bit misleading since all three hormones play a role in weight loss. Leptin and PYY are known to suppress appetite, while ghrelin stimulates appetite. Ghrelin has been shown to have more of an effect on weight regulation than leptin or PYY, but more research is needed to determine if it is the most important hormone for weight loss. In the meantime, anyone trying to lose weight should focus on eating healthy foods and exercising regularly, regardless of which hormone is most important.
Which of the following hormones suppresses appetite and increases energy expenditure?
Research shows that ghrelin may play a more significant role in weight loss than either leptin or PYY. Ghrelin stimulates appetite, while leptin and PYY are known to suppress appetite. However, more research is needed to determine which of these hormones has the strongest effect on weight loss. In the meantime, anyone trying to lose weight should focus on eating healthy foods and exercising regularly, regardless of which hormone is most important.
