The world is buzzing about semaglutide, often hailed as a “miracle drug” for weight loss. But what is it, and how does it work? Let’s break it down into simple terms.
Semaglutide: How It Works
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). This means it mimics the GLP-1 hormone, which helps regulate hunger and feelings of fullness. Additionally, it prompts the body to produce more insulin and reduce blood sugar levels by slowing down the rate at which food travels through the digestive system, making it a common treatment for Type 2 diabetes.
Semaglutide Brands and FDA Approval
There are three semaglutide brands in the US that have been approved by the FDA: Ozempic, Wegovy, and Rybelsus. It became FDA-approved in 2017 for diabetes treatment under the name Ozempic, and in 2021, the FDA approved it specifically for weight loss under the brand name Wegovy. For weight loss, the typical dose is 2.4 milligrams, administered weekly as a subcutaneous injection (under the skin).
Possible Side Effects
Just like with any other medication, semaglutide can cause side effects, which are typically mild. Some common side effects include:
- Dizziness
- Fatigue
- Gastrointestinal issues (such as diarrhea, constipation, and gas)
- Stomach issues (such as nausea, vomiting, pain, or bloating)
Gastrointestinal issues are the most common complaint among new users. To manage these side effects, it’s recommended to start with a lower dose and gradually increase it, stay hydrated, and use medication for symptom control as needed.
Other Concerns
Availability
Due to its growing popularity, there may be shortages of semaglutide. Some medi spas and boutique weight loss practices prescribe semaglutide as “off the label” to people who don’t necessarily meet criteria to receive the medication, leading to scarcity for those who genuinely need it. (“Off-label” means prescribing it for a condition other than those officially approved by the FDA.) To meet the criteria and become eligible to receive semaglutide, you need to have a BMI of 30 kg/m2, or a BMI of 27 kg/m2 or higher and a weight-related condition.
Although there are no approved generic versions of the weight loss shot Wegovy, it meets the Federal Food, Drug, and Cosmetic (FD&C) Act requirements to be compounded. Federal law allows compounding pharmacies to make copies of FDA-approved drugs when they are listed as “currently in shortage” on the FDA’s Drug Shortage list. This is to ensure patient care can continue while manufacturers are struggling to meet demand.
Cost
Semaglutide can be expensive. For example, the list price for a 0.25, 0.5, 1, or 2 mg injection pen ranges around $935.77 and can cost up to $1,400 if you do not have insurance coverage. Keep in mind that your insurance might not cover the cost of semaglutide when used off-label, unless you have a pre-existing condition related to weight loss such as diabetes or hypertension.
Some insurances will not cover weight loss medications as a benefit. Or, they may require medical providers to fill out additional paperwork and preauthorizations prior to approval. Compounded semaglutide is not covered by insurance, but it is often less than half the cost of the name brand drug from a pharmacy.
Where to Get Semaglutide: Weight Loss
If you need semaglutide but don’t have health insurance, consider applying for patient assistance programs and using prescription discount coupons from pharmacies. Additionally, buying in bulk from the manufacturer may lead to discounts, though this practice may contribute to drug shortages. You can also check out online semaglutide weight loss clinics such as Klinic to inquire about starting your medical weight loss journey with compounded semaglutide.
Longevity
When you consult with a provider at a weight loss clinic, semaglutide may be prescribed based on your specific needs and current health. Yet, achieving significant weight loss with semaglutide is not a short-term solution. To maintain your results, you’ll need to stay on the medication long-term. Be prepared for ongoing use to achieve and sustain its health benefits. This is because the benefits of semaglutide, including appetite suppression and improved insulin sensitivity, continue only as long as the medication is taken.
Regular check-ins with your healthcare provider are also essential while on semaglutide. They will monitor your progress, adjust dosages as needed, and address any side effects or concerns you may have. This ongoing medical supervision ensures the medication remains safe and effective for your specific health needs.
Final Thoughts
For many who have struggled with weight loss, semaglutide has been life-changing. If you’re considering it, discuss with your healthcare provider to assess the pros and cons, including cost, long-term use, and effectiveness.
Remember, no medication is a magic bullet for weight loss. Even with semaglutide, maintaining a healthy lifestyle is crucial. A balanced diet, regular exercise, good hydration, and quality sleep are essential for overall health and successful weight management.
By staying informed and working closely with your healthcare provider, you can make the best decision for your weight loss journey.